Bovine growth hormone: human food safety evaluation

[Bovine spongiform encephalopathy and food safety].

The governments of Great Britain and France disagree on the safety of British beef with respect to bovine spongiform encephalopathy (BSE). Eventually the consumer might have the burden to decide whether beef from Britain is safe to eat with regard to the new variant of Creutzfeldt-Jakob disease (vCJD). Outside Britain the incidence of BSE increases. Probably in continental Europe, the use of hi...

Evaluation of Heat Induction Strategy for Recombinant Human Growth Hormone Expression in Fed-Batch Fermentation

Long-term safety of recombinant human growth hormone in children.

BACKGROUND Between 1985 and 2006, the National Cooperative Growth Study (NCGS) monitored the safety and efficacy of recombinant human growth hormone (rhGH) in 54,996 children. METHODS Enrolled patients were followed until rhGH discontinuation. Investigators submitted adverse event reports for targeted events or those potentially rhGH-related. RESULTS Early concerns about de novo leukemia in...

Monoclonal antibodies against bovine growth hormone.

A number of mouse x mouse hybridomas producing monoclonal antibodies (MAbs) against bovine growth hormone (bGH) were prepared by fusion of spleen cells from bGH-primed mice (Balb/c) with non-secretory mouse myeloma cells (PAIOP3) and characterized. MAbs obtained from three fusion experiments belonged to IgM, IgG1 and IgG2b class/subclass of antibodies. Cross-reaction studies indicated that gene...

Structural Studies on Bovine Growth Hormone

Purified bovine growth hormone, consisting of a single polypeptide chain, has been found to contain NHz-terminal alanine, phenylalanine, and methionine in nearly equal amounts. The minimum molecular weight calculated from its amino acid composition is 20,846. Five unique fragments have been prepared from bovine growth hormone by cleavage at 4 methionyl residues with cyanogen bromide. In the ord...